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Wednesday, April 26 • 12:30pm - 2:00pm
Developing Patch Clamp Analysis Techniques to Deorphanize VSNRs

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Major urinary proteins (MUPs) are a class of species-specific pheromones that have been found to produce consistent and specific behavioral responses in mice independent of prior conditioning. MUPs are detected through an accessory olfactory system known as the vomeronasal organ, which expresses sensory receptors (VSNRs) designed for MUP binding. Here the activity of VNSRs is intended to be studied using patch clamp analysis by recording VNSR activation upon exposure to specific MUPs as evidenced by voltage change. CHO cells will be transfected to express VNSRs for analysis. The current primary goal includes developing an effective patch clamp protocol allowing for whole cell electrophysiological recording. This research is proposed to allow for the future tracing of synaptic projections throughout the brain beginning with VSNR activation, providing insight into the neurological basis of behavioral reactions.


Wednesday April 26, 2017 12:30pm - 2:00pm
Concourse - Wilma Sherrill Center

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