Synthesis of pyrazoline derivatives has been an active field of research due to the established biological and pharmaceutical activities of these compounds such as antibacterial, anti-inflammatory, and anticancer properties. Pyrazoline derivatives are produced from the cyclization of chalcones with hydrazine hydrate and aryl aldehyde in the presence of ethanol. Due to the pharmacological effects associated with both chalcone and pyrazoline derivatives, it has been hypothesized that synthesizing a pyrazoline derivative from chalcone will enhance the product’s biological activity. However, the total synthesis of pyrazoline derivatives has been proven to be challenging due to its “one pot” synthesis producing low yields. Progress towards the synthesis of an unsubstituted pyrazoline derivative stemming from the reaction between an unsubstituted chalcone, hydrazine hydrate, and benzaldehyde in the presence of ethanol is presented. The synthetic pathway includes the formation of an unsubstituted chalcone via a Claisen Schmidt condensation to be used as a starting material. The reaction scheme for the unsubstituted pyrazoline acts as a basis for other research projects as the derivative is amenable to the addition of various functional groups. Modifications to enhance the activity of the pyrazoline derivative will be made, including the addition of methoxy groups.
