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Wednesday, April 26 • 8:30am - 10:00am
Synthesis and Antibacterial Evaluation of the Natural Product Pseudopyronine A, and Core α-Pyrone Derivatives

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With antibiotic resistance becoming an increasing problem in society it is vital for chemists to search for more possibilities for antibacterial products to combat this growing issue. α-Pyrone analogs of Pseudopyronine A, an antibacterial natural product isolated from Pseudomonas species, are being synthesized and evaluated for improved antibacterial activity against both Gram positive and Gram negative bacteria such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa. Synthetic analogs are accessed through either the commercially available acyl chloride or β-ketoesters, which will produce the α-pyrone in 5 or 3 steps respectively. The α-pyrones will then be further derivatized through alkylation, amidation, or halogenation reactions. All derivatives will then be evaluated for antibacterial activity in a growth inhibition assay against a panel of both Gram-positive and -negative bacteria.


Wednesday April 26, 2017 8:30am - 10:00am PDT
Concourse - Wilma Sherrill Center